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1)	NAME OF REPORTING PERSONS   Gilder, Gagnon, Howe & Co. LLC
2)	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP			(a)       o (b)       o
3)	SEC USE ONLY
4)	CITIZENSHIP OR PLACE OF ORGANIZATION   New York
	NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH	5)	SOLE VOTING POWER   67,011
		6)	SHARED VOTING POWER   None
		7)	SOLE DISPOSITIVE POWER   67,011
		8)	SHARED DISPOSITIVE POWER   3,361,120
9)	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON   3,428,131
10)	CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES o
11)	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)   6.2%
12)	TYPE OF REPORTING PERSON   BD

 

 

 

Item 1(a).

Name of Issuer:

 

NxStage Medical, Inc.

 

 

 

 

Item 2(b).

Address of Principal Business Office or, if None, Residence:

 

 

Item 2(c).

Citizenship:

 

 

Item 2(d).

Title of Class of Securities:

 

 

Item 2(e).

CUSIP Number:

 

 

 

 

(b)

¨

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

 

(c)

¨

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

 

(d)

¨

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

 

(e)

¨

An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

 

 

(g)

¨

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

 

 

 

 

 

(h)

¨

A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

 

(k)

¨

Group, in accordance with § 240.13d-1(b)(1)(ii)(K).

 

Item 4.

Ownership.

 

(a)

Amount beneficially owned:  3,428,131

 

(b)

Percent of class:  6.2%

 

(c)

Number of shares as to which such person has:

 

(i)

Sole power to vote or to direct the vote:  67,011

 

(ii)

Shared power to vote or to direct the vote:  None

 

(iii)

Sole power to dispose or to direct the disposition of:  67,011

 

(iv)

Shared power to dispose or to direct the disposition of:  3,361,120

 

The shares reported include 2,962,732 shares held in customer accounts over which partners and/or employees of the Reporting Person have discretionary authority to dispose of or direct the disposition of the shares, 398,388 shares held in accounts owned by the partners of the Reporting Person and their families, and 67,011 shares held in the account of the profit-sharing plan of the Reporting Person (the “Profit-Sharing Plan”).

 

Item 5.

Ownership of Five Percent or Less of a Class.

 

 

 

 

 

 

 

 

 

 

 

Item 9.

Notice of Dissolution of Group.

 

 

Item 10.

Certification.